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VR1814 gB(585G) can also activate caspase-2. (A) Caspase-2 was activated upon infection of MRC-5 cells with HCMV strain VR1814. (B) UL55 sequence alignment of FIX and VR1814. (C) FIX gB(585S) was changed to 585G by BAC mutagenesis (2 clones are shown). Caspase-2 activation was analyzed by immunoblot. The data shown are representative of 3 (A) or 2 (B) independent experiments.
