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. 2019 Sep 4;9(9):e030689. doi: 10.1136/bmjopen-2019-030689

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Genetic testing phase for relatives and subsequent enrolment to the ZiPP study. The figure provides an overview of the process and procedures for genetic testing of relatives as well as an outline of the flow of subjects who consented to participate in the intervention and observational studies. PRISM, Paget's Disease: Randomised Trial of Intensive versus Symptomatic Management; SQSTM1, sequestosome-1; ZiPP, Zoledronic acid in the Prevention of Paget’s disease.