Table 2.
Laboratory data at serial treatment time-points
| Variable | T0 (n=71) | T6 (n=71) | T12 (n=59) | T18 (n=58) | P-value |
|---|---|---|---|---|---|
| BCR-ABL, % (All patients) | 63.81 (53.44–74.37) | 4.83 (1.73–10.82) | 1.07 (0.28–2.98) | 0.51 (0.09–1.81) | <0.001a 0.008b |
| BCR-ABL, % (Low-NRBC) | 58.04 (48.61–74.54) | 1.59 (0.06–9.92) | 0.60 (0.04–2.66) | 0.09 (0.04–0.67) | <0.001a 0.069b |
| BCR-ABL, % (High-NRBC) | 71.35 (52.47–80.93) | 12.15 (4.09–26.17) | 7.73 (3.47–25.07) | 17.04 (2.10–38.86) | <0.001a 0.724b |
| RBC, ×1012/L | 3.26 (3.08–3.41) | 3.73 (3.57–4.02) | 3.71 (3.46–3.94) | 3.70 (3.51–3.86) | <0.001a 0.754b |
| NRBC, ×109/L | 0.043 (0.000–0.253) | 0.000 (0.000–0.001) | 0.000 (0.000–0.002) | 0.000 (0.000–0.000) | <0.001a 0.766b |
| WBC, ×109/L | 160.7 (138.4–185.7) | 5.5 (4.8–6.2) | 5.5 (4.3–6.1) | 5.5 (4.8–6.3) | <0.001a 0.582b |
| Blast cells, % | 1.6 (1.3–1.9) | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | <0.001a 0.998b |
| BASO, % | 7.5 (6.7–8.9) | 0.5 (0.4–0.5) | 0.5 (0.4–0.7) | 0.6 (0.5–0.6) | <0.001a 0.070b |
| PLT, ×109/L | 402 (352–487) | 157 (126–162) | 157 (135–176) | 183 (163–204) | <0.001a 0.004b |
| Uric acid, mg/dL | 5.52 (4.92–6.32) | 4.74 (4.12–5.80) | 4.95 (4.71–5.59) | 5.11 (4.69–5.46) | 0.776a 0.968b |
| Bilirubin, mg/dL | 0.59 (0.53–0.67) | 0.60 (0.55–0.70) | 0.60 (0.51–0.71) | 0.60 (0.52–0.67) | 0.802a 0.618b |
| Creatinine, mg/dL | 0.75 (0.70–0.81) | 0.71 (0.70–0.81) | 0.75 (0.70–0.80) | 0.78 (0.70–0.80) | 0.284a 0.104b |
| Sodium, mmol/L | 138.0 (138.0–139.0) | 139.5 (138.9–140.1) | 139.2 (138.6–139.7) | 139.2 (138.7–139.7) | 0.091a 0.480b |
| Potassium, mmol/L | 3.89 (3.70–3.99) | 3.62 (3.57–3.70) | 3.64 (3.60–3.75) | 3.67 (3.61–3.83) | 0.001a 0.252b |
| Chloride, mmol/L | 104.8 (104.0–105.4) | 107.1 (106.2–108.0) | 107.2 (106.6–107.9) | 107.0 (106.4–107.6) | 0.003a 0.962b |
| Calcium, mmol/L | 2.2 (2.1–2.2) | 2.2 (2.1–2.2) | 2.2 (2.2–2.2) | 2.2 (2.2–2.2) | 0.673a 0.577b |
Notes: Results were presented as median with 95% confident interval (95% CI); High-NRBC: NRBC≥0.003×109/L; Low-NRBC: NRBC<0.003×109/L; aT6, T12, T18 versus T0. bT6 versus T12 versus T18.
Abbreviations: RBC, red blood cells; WBC, white blood cells; BASO, basophils; NRBC, nucleated red blood cells; PLT, platelets; T0, at diagnosis; T6, after 6 months of treatment; T12, after 12 months of treatment; T18, after 18 months of treatment.