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. 2019 Sep 3;11:8167–8179. doi: 10.2147/CMAR.S209904

Figure 1.

Figure 1

HOXC6 is overexpressed in GBM. (A) HOXC6 mRNA expression of GBM tissues is higher than normal tissues due to ONCOMINE. Cell color was determined by the best gene rank percentile for the analysis within the cells. The threshold is as following: P-value=1E-4, fold change=1.5, gene rank=top 10%. (B) HOXC6 expression was associated with OS (n=152, p=0.0139) according to Kaplan–Meier analysis from OncoLnc database. (C) The mRNA levels of HOXC6 from 14 normal brain tissue samples, 18 samples of low-grade glioblastoma tissue samples and 21 samples of high-grade glioblastoma tissue samples were tested by quantitative PCR using unpaired t-test. (D) Protein levels of HOXC6 in 6 paired glioblastoma tissues and its adjacent normal tissues by Western blotting. (E) HOXC6 mRNA expression levels in 5 GBM cell lines (A172, U251, U87, U118, LN229) and in 1 human astrocyte (NHA) were examined by quantitative PCR using t-test. (F) HOXC6 protein expression in 5 GBM cell lines (A172, U251, U87, U118, LN229) and in 1 human astrocyte (NHA) was examined by Western blotting. *p<0.05, **p<0.01, ***p<0.001.