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. 2019 Sep 3;12:7203–7214. doi: 10.2147/OTT.S194800

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© 2019 Liang et al.

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Effect of miR-765 on cisplatin sensitivity through APE1 inhibition. (A and B) 9901/HOS cells were transfected with miR-765 mimics or the miR mimic negative control (miR NC) for 48 hrs. Cell viability was assayed by CCK-8 after treatment with increasing concentrations of cisplatin for 48 hrs. Data are shown as the mean ±95% confidence interval from three independent experiments. (C and D) 9901/HOS cells were transfected with APE1 siRNA or the siRNA negative control (miR NC) for 48 hrs. Cell viability was assayed by CCK-8 after treatment with increasing concentrations of cisplatin for 48 hrs. Data are shown as the mean ±95% confidence interval from three independent experiments. (E and F) 9901/HOS cells were cotransfected with miR-765 mimics and siAPE1 (siNC) for 48 hrs. Cell viability was assayed by CCK-8 after treatment with increasing concentrations of cisplatin for 48 hrs. Data are shown as the mean ±95% confidence interval from three independent experiments.