A-B) Endothelium-dependent acetylcholine (Ach) induced relaxation in wild type (A, Kit+/+) and c-Kit deficient (B, KitW/W-v) mesenteric arteries in the presence or absence of eNOS and prostaglandin-endoperoxide synthase inhibitors, L-NAME and indomethacin, respectively. C-E) Comparison of vasorelaxation curves from wild type and c-Kit deficient arteries under control conditions (C, no inhibitor), and after incubation with L-NAME (D) or indomethacin (E). Errors bars at each concentration point represent the mean±standard error of the mean (SEM).*P<0.05,**P<0.01,***P<0.001.