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. Author manuscript; available in PMC: 2020 Oct 15.
Published in final edited form as: Eur J Pharmacol. 2019 Aug 14;861:172592. doi: 10.1016/j.ejphar.2019.172592

Figure 2:

Figure 2:

Chronic memantine time-effect function for effects on nicotine self-administration, weekly averages (mean of nicotine infusions per session ± S.E.M.). Significant (P < 0.05) memantine-induced decreases in nicotine self-administration were seen during the second week of treatment and during the week after the end of treatment. No significant effects of memantine on nicotine self-administration were seen during the first week of treatment or during the resumed treatment after a week of enforced abstinence.