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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Addiction. 2019 Jul 8;114(10):1824–1833. doi: 10.1111/add.14695

Table 1.

Mean or geometric mean of area under the curve by multiple imputation across intervention conditions1

Endpoint Immediate Gradual Control
8-iso-PGF2α AUC (pmol/mg creatinine), geometric mean 1.15 1.19 1.19
hs-CRP AUC (mg/L), geometric mean 2.74 3.01 2.53
hs-CRP AUC (mg/L), ≤10 only,2 geometric mean 2.17 2.41 2.02
WBC AUC (103/μL), mean 7.55 7.71 7.47
WBC AUC (103/μL), ≤14 only,2 mean 7.49 7.62 7.41
PGEM AUC (pmol/mg creatinine), geometric mean 57.25 57.55 60.46
Red cell count (106/μL), mean 4.73 4.77 4.70
Hemoglobin (g/dL), mean 14.23 14.28 14.22
Hematocrit (%), mean 43.00 43.13 42.86
MCV (fL), mean 91.16 90.72 91.50
MCH (pg), mean 30.13 29.98 30.26
MCHC (g/dL), mean 33.05 33.01 33.09
RDW (%), mean 13.86 14.00 13.98
Platelet count (103/μL), mean 246.39 243.73 244.71
MPV (fL), mean 10.00 10.03 9.84
1

Unadjusted mean or geometric mean of area under the curve for imputed data by using the Markov Chain Monte Carlo (MCMC) based multiple imputation method.

2

Exclusion of out-of-range values

Abbreviation and range: 8isoPGF2α (pmol/mg), (Z)-7-[1R,2R,3R,5S]-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid) or 8-iso-prostaglandin F2α; hs-CRP, high sensitivity C Reactive Protein, lower risk: 0 – 2 mg/L (58, 59); WBC (103/μL), white cell count, normal range: 3.8-11.0; PGEM (pmol/ml), Prostaglandin E Metabolite; Red cell count (106/μL), normal range: female 3.75-5.40, male 4.10-6.20; Hemoglobin (g/dL), normal range: female 11.5-16.0, male 12.5-18.0; Hematocrit (%), normal range: female 34.8-47, male 36.0-54.0; MCV (fL), mean corpuscular volume (measure of size of red blood cells), normal range: 80-100; MCH (pg), mean corpuscular hemoglobin (quantity of hemoglobin in red blood cell), normal range: 27.0-34.0; MCHC (g/dL), mean corpuscular hemoglobin concentration (concentration of hemoglobin in red blood cells), normal range: 31.5-36.5; RDW (%), red blood cell distribution width, (variation in size and volume of red blood cells), normal range: 11.0-15.6; Platelet count (103/μL), normal range: 140-440; MPV (fL), mean platelet volume (size of platelet), normal range: 7.0-12.4