Table 2.

Gene Ontology results for t-tubule proteins.

A. HPASubC-identified t-tubule proteins (N=96)
GO Biological Process	Fold Enrichment	P value
1. Cell differentiation	2.63	3.55E-06
2. Cellular developmental process	2.58	6.88E-06
3. Muscle contraction	10.05	1.64E-04
GO Cellular Component	Fold Enrichment	P value
1. Sarcolemma	31.50	2.49E-19
2. Membrane microdomain	11.78	1.17E-09
31. T-tubule	21.52	7.70E-03
B. Literature-identified t-tubule proteins (N=50)
GO Biological Process	Fold Enrichment	P value
1. Regulation of localization	6.09	1.27E-20
2. Regulation of ion transmembrane transport	20.67	1.20E-19
3. Regulation of heart contraction	37.5	1.23E-19
GO Cellular Component	Fold Enrichment	P value
1. Contractile fiber part	41.30	2.79E-25
2. Myofibril	40.73	3.67E-25
14. T-tubule	80.93	2.97E-13
C. Combined t-tubule proteins (N=129)
GO Biological Process	Fold Enrichment	P value
1. Regulation of heart contraction	18.04	9.85E-17
2. Regulation of localization	3.66	4.50E-16
3. Muscle system process	13.62	6.63E-16
GO Cellular Component	Fold Enrichment	P value
1. Sarcolemma	35.59	1.24E-31
2. Contractile fiber	17.93	3.39E-20
18. T-tubule	35.05	1.56E-10