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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Cardiovasc Pathol. 2019 May 24;42:15–20. doi: 10.1016/j.carpath.2019.05.001

Table 2.

Gene Ontology results for t-tubule proteins.

A. HPASubC-identified t-tubule proteins (N=96)
GO Biological Process Fold Enrichment P value
1. Cell differentiation 2.63 3.55E-06
2. Cellular developmental process 2.58 6.88E-06
3. Muscle contraction 10.05 1.64E-04
GO Cellular Component Fold Enrichment P value
1. Sarcolemma 31.50 2.49E-19
2. Membrane microdomain 11.78 1.17E-09
31. T-tubule 21.52 7.70E-03
B. Literature-identified t-tubule proteins (N=50)
GO Biological Process Fold Enrichment P value
1. Regulation of localization 6.09 1.27E-20
2. Regulation of ion transmembrane transport 20.67 1.20E-19
3. Regulation of heart contraction 37.5 1.23E-19
GO Cellular Component Fold Enrichment P value
1. Contractile fiber part 41.30 2.79E-25
2. Myofibril 40.73 3.67E-25
14. T-tubule 80.93 2.97E-13
C. Combined t-tubule proteins (N=129)
GO Biological Process Fold Enrichment P value
1. Regulation of heart contraction 18.04 9.85E-17
2. Regulation of localization 3.66 4.50E-16
3. Muscle system process 13.62 6.63E-16
GO Cellular Component Fold Enrichment P value
1. Sarcolemma 35.59 1.24E-31
2. Contractile fiber 17.93 3.39E-20
18. T-tubule 35.05 1.56E-10