Table 4.
Association between tertiles of serum 25(OH)D and change in executive function and memory domains, as odds of >=1SD decline.
| Baseline Serum 25(OH)D Tertile | |||||
|---|---|---|---|---|---|
| Tertile 1 | Tertile 2 | Tertile 3 | p-trend | ||
| Executive Function Component Score Decline (>=1SD) | |||||
| OR (95% CI) | Crudea | 1.16 (0.50, 2.69) |
1.46 (0.67, 3.25) |
REF | 0.62 |
| OR (95% CI) | Multivb | 1.16 (0.50, 2.71) |
1.81 (0.67, 3.25) |
REF | 0.58 |
| Memory Component Score Decline (>=1SD) | |||||
| OR (95% CI) | Crudea | 1.07 (0.63, 1.80) |
0.87 (0.52, 1.48) |
REF | 0.73 |
| OR (95% CI) | Multivb | 1.09 (0.62, 1.92) |
0.83 (0.47, 1.45) |
REF | 0.81 |
a
adjusted for age, sex and baseline score
b
multivariable model, adjusted for age in years, sex, season of blood collection, physical activity (physical activity (PA) score <30, PA score 30–40, PA score 40–50, PA score >=50), education (<5th grade, 5–8th grade, 9–12 grade, some college or college degree, some graduate school), diabetes (yes/no), smoking (never/past/current), alcohol use (never/past current), hypertension (yes/no), BMI (normal weight/overweight/obese), multivitamin supplement use (yes/no), CRP, and APOE (presence of APOE 4).