Table 1.
Subject Characteristics
| AA | AC | HC | p value | |
|---|---|---|---|---|
| Subjects, n | 20 | 22 | 3 | |
| Age, yr, mean (SD) | 28.7 (9.3) | 27.2 (7.7) | 24 (2.3) | .935 |
| Female, n (%) | 11 (61.1) | 10 (45.5) | 2 (66.6) | .546 |
| FEV1, mean (SD) | ||||
| -Liters | 3.31 (0.79) | 4.02 (0.68) | 3.76 (0.34) | .071 |
| -% predicted | 88.9 (10.6)† | 103.1 (12.9) | 102.7 (7.77) | .004 |
| FVC, mean (SD) | ||||
| -Liters | 4.46 (1.31) | 4.83 (0.82) | 4.30 (0.34) | .306 |
| -% predicted | 100.3 (12.2) | 104.9 (14.0) | 101.7 (7.51) | .294 |
| FEV1/FVC, mean (SD) | 0.76 (0.08)†‡ | 0.84 (0.05) | 0.87 (0.02) | .0005 |
| PC20, mg/mL, mean (SD) | 3.50 (5.38)†‡ | > 25 | > 25 | <.0001 |
| Allergen, n (%) | ||||
| -D. pteronyssinus | 12 (60) | 10 (45.5) | - | |
| -Cat hair extract | 8 (40) | 12 (54.5) | - | |
| Allergen Dose, BAU/mL, mean (SD) | ||||
| -D. pteronyssinus | 226.2(339.0) | 110.1(108.2) | - | 0.847* |
| -Cat hair extract | 158.7(172.0) | 751.7(418.6) | 500 (0) | 0.0042* |
Definition of abbreviations: AA = allergic asthmatic; AC = allergic control; BAU = bioequivalent allergen unit; PC20 = concentration of methacholine needed to produce a 20% fall in FEV1 from baseline.
†
p < 0.05 for post hoc comparison with AC.
‡
p < 0.05 for post hoc comparison with HC.
*
HC group excluded and Mann-Whitney test used for statistical analysis.