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. Author manuscript; available in PMC: 2020 Feb 6.
Published in final edited form as: J Am Chem Soc. 2019 Jan 28;141(5):1893–1897. doi: 10.1021/jacs.8b13094

Figure 4.

Figure 4.

A) Schematic view of generating 3a-labeled αS-PpY114 pre-formed fibrils (3a-pffs) and photoconverted fibrils (3a-PC-pffs). B) MALDI-MS and C) SDS-PAGE analysis of wild-type (WT) and 3a-labeled αS-PpY114 (αS-PpY3a114) irradiated for 0 or 6h. FITC (λex = 473nm, λem = 520nm) TMR (λex = 532nm, λem = 580nm) filters are used. D-E) Emission spectra upon photoirradiation to measure disappearance of 3a-pffs and appearance of 3a-PC-pffs. PpY is propargyl tyrosine and MW is molecular weight standards.