Table A1.
Biological and mediated pleiotropy depressive symptoms polygenic score regression results for mean CES-D and cigarettes per day, European ancestry, N=4641
| Outcome | CES-D | Cigarettes Smoked per Day (CPD) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | Model 6 | ||||||||
| Beta (SE) | P-value | Beta (SE) | P-value | Beta (SE) | P-value | Beta (SE) | P-value | Beta (SE) | P-value | Beta (SE) | P-value | Beta (SE) | P-value | |
| DS PGS (std) | 0.174* | 5.93E-14 | −0.103 | 0.694 | −0.176 | 0.502 | −0.115 | 0.656 | −0.198 | 0.431 | −0.299 | 0.393 | −0.247 | 0.587 |
| (0.023) | (0.261) | (0.262) | (0.257) | (0.252) | (0.350) | (0.455) | ||||||||
| Mean CES-D | 0.423 | 0.011 | 0.704* | 3.65E-05 | 1.024* | 1.21E-09 | 1.023* | 1.25E-09 | 1.166* | 7.31E-06 | ||||
| (0.166) | (0.170) | (0.168) | (0.168) | (0.260) | ||||||||||
| Female | −6.918* | 2.25E-45 | −6.922* | 2.15E-45 | −6.636* | 2.39E-24 | ||||||||
| (0.484) | (0.484) | (0.648) | ||||||||||||
| DS PGS × Female | 0.198 | 0.678 | 0.376 | 0.558 | ||||||||||
| (0.477) | (0.642) | |||||||||||||
| DS PGS × CES-D | −0.062 | 0.809 | ||||||||||||
| (0.257) | ||||||||||||||
| CES-D × Female | −0.211 | 0.525 | ||||||||||||
| (0.332) | ||||||||||||||
| DS PGS × CES-D × Female | −0.075 | 0.819 | ||||||||||||
| (0.327) | ||||||||||||||
| Age | −0.399* | 0.0001 | −0.576* | 1.32E-08 | −0.575* | 1.36E-08 | −0.575* | 1.39E-08 | ||||||
| (0.103) | (0.101) | (0.101) | (0.101) | |||||||||||
| Current smoker | −3.134* | 6.86E-10 | −2.815* | 1.53E-08 | −2.814* | 1.56E-08 | −2.823* | 1.43E-08 | ||||||
| (0.507) | (0.497) | (0.497) | (0.497) | |||||||||||
| GED/HS Degree | −2.859* | 0.0001 | −.889* | 7.92E-05 | −2.883* | 8.20E-05 | −2.894* | 7.84E-05 | ||||||
| (0.747) | (0.731) | (0.731) | (0.732) | |||||||||||
| R2 | 0.019 | 0.004 | 0.005 | 0.045 | 0.085 | 0.085 | 0.086 | |||||||
Note. CPD: cigarettes per day; CES-D: Center for Epidemiological Studies-Depression 8 item scale; PGS: Polygenic score; DS: Depressive symptoms; GED: General Education Degree; HS: High School degree; SE: standard errors. All models adjust for 10 European ancestry PCs and birth cohort. Sample includes current or former smokers only. Bonferroni-adjusted alpha level:
p<0.006.
M1: CES-D/CPD = PGS + PCS
M2: CPD = PGS + CES-D + PCS
M3: CPD = PGS + CES-D + PCS + CURRENT SMOKER + AGE + GED/HS + COHORT
M4: CPD = PGS + CES-D + FEMALE + PCS + CURRENT SMOKER + AGE + GED/HS + COHORT
M5: CPD = PGS + CES-D + FEMALE + FEMALE×PGS + PCS + CURRENT SMOKER + AGE + GED/HS + COHORT
M6: CPD = PGS + CES-D + FEMALE + FEMALE×PGS + PGS×CES-D + CES-D×FEMALE + PGS×CES-D×FEMALE + PCS + CURRENT SMOKER +AGE + GED/HS + COHORT