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. Author manuscript; available in PMC: 2019 Sep 8.
Published in final edited form as: Neuron Glia Biol. 2011 Dec 14;6(4):277–288. doi: 10.1017/S1740925X11000111

Fig. 3. Administration of ACPD attenuates white matter loss after HI in postnatal day 6 (P6) Long-Evans rats.

Fig. 3.

HI results in the significant loss of MBP in the hemisphere ipsilateral to carotid ligation (A), compared to MBP expression in the uninjured, contralateral hemisphere (B). Systemic administration of ACPD for 48 h significantly attenuates callosal and periventricular white matter loss 96 h following HI when administered at 5 mg kg−1 (C,D) or 2o mg kg−1 (E,F). Treatment with ACPD preserves myelin processes radiating into the cortex and pericallosal process bundles at each dose examined (C,E) compared to vehicle-treated controls, and significantly decreases overall MBP injury scores (G).