Table 2.
Cell profile counts in putamen at the anterior and posterior levels
| Parameter/ Group | Anterior level |
Posterior Level |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | H&E viable neurons |
n | H&E ischemic neurons |
n | H&E apoptotic profiles |
n | TUNEL profiles |
n | H&E viable neurons |
n | H&E ischemic neurons |
n | H&E apoptotic profiles |
n | TUNEL profiles |
|
| Naive | 5 | 100.8 (98.7– 124.2) | 5 | 0 (0– 0.1) | 5 | 1.2 (1.0– 2.8) | 6 | 0.5 (0.3– 0.8) | 6 | 79.4 (65.2– 87.8) | 6 | 2.1 (0.2– 3.7) | 6 | 0.4 (0.2– 0.9) | 6 | 0.2 (0.1– 0.3) |
| Sham NormoT | 8 | 112.2 (98.1– 129.0) | 8 | 0 (0– 0) | 8 | 0.5 (0.2– 0.6) | 7 | 0.8 (0.5– 1.9) | 8 | 84.3 (75.9– 97.8) | 8 | 0.6 (0.2– 2.6 | 8 | 0.4 (0.2– 1.0) | 8 | 0.2 (0.1– 0.3) |
| Sham HypoT | 7 | 68.1 (67.8– 81.8) | 7 | 0.4 (0.4– 1.0) | 7 | 5.0 (0.9– 6.5) | 6 | 1.4 (0.5– 2.3) | 6 | 85.9 (74.5– 107.7) | 6 | 1.0 (0.1– 2.6) | 6 | 1.5 (0.9– 2.0) | 7 | 1.7 (1.1– 2.5) |
| Sham Rewarm | 7 | 86.3 (67.3– 96.0) | 7 | 0.8 (0.2– 4.5) | 7 | 0.4 (0.2– 0.7) | 7 | 0.6 (0.4– 0.8) | 7 | 71.0 (59.3– 75.2) | 7 | 3.6 (1.7– 9.5) | 7 | 0.3 (0.2– 0.9) | 6 | 0.2 (0.1– 0.4) |
| HI NormoT | 6 | 76.8 (52.4– 92.2) | 6 | 1.5 (0.1– 12.4) | 6 | 2.2 (1.8– 3.2) | 5 | 0.8 (0.4– 1.2) | 6 | 67.9 (55.3– 90.5) | 6 | 1.4 (0.8– 7.6) | 6 | 0.9 (0.7– 2.1) | 4 | 1.3 (0.7– 1.3) |
| HI HypoT | 7 | 111.9 (108.3– 127.6) | 7 | 0 (0–0) | 7 | 1.8 (0.9– 2.5) | 8 | 0.5 (0.3– 0.8) | 8 | 93.0 (83.9– 99.7) | 8 | 0.6 (0.2– 2.3) | 8 | 0.6 (0.3– 0.8) | 8 | 0.4 (0.2– 0.8) |
| HI Rewarm | 8 | 104.7 (96.6– 119.9) | 8 | 0 (0– 1.4) | 8 | 4.2 (0.8– 8.2) | 6 | 0.7 (0.5– 1.0) | 8 | 102.0 (88.9– 108.3) | 8 | 1.0 (0.3– 4.2) | 8 | 0.8 (0.6– 1.0) | 7 | 0.3 (0.2– 0.6) |
All data are presented as median (IQR).
H&E, hematoxylin and eosin; TUNEL, terminal deoxynucleotidyl transferase dUTP nick-end labeling; NormoT, sustained normothermia; HI, hypoxia-ischemia; HypoT, sustained hypothermia; Rewarm, hypothermia followed by rewarming.