TABLE 4:

The strongest models for predicting each objective cognitive measure (MMSE, ADAS_Cog, ADNI-EF, ADNI-MEM) and each ECog domain (Memory, Language, Visuospatial, Planning, Organization, Divided Attention).

	All CN subjects		Aβ-negative CN subjects
Outcome	Best model	Adjusted R²	Best model	Adjusted R²
Objective Cognitive Measures
MMSE	Aβ(temp^, par^), Age^*	0.34	Age^*, Aβ(front^⋅)	0.14
ADAS-Cog	Aβ(par^), Age^	0.29	Age^*, Aβ(temp)	0.18
ADNI-EF	Aβ(front^), Age^	0.18	Age^, APOE-Ɛ4, Tau(Braak III-IV^⋅), Aβ(par^⋅, temp^⋅, cing^, front^*)	0.31
ADNI-MEM	Aβ(front^), Age^, Tau(Braak III-IV, Braak V-VI)	0.19	Aβ(front^, cing^), Sex^⋅, Age, Tau(Braak III-IV)	0.20
Subjective Cognitive Measures
Everyday Memory	Aβ (par^*), Age, Sex	0.17	Aβ (cing^⋅), Age^⋅, APOE-Ɛ4	0.11
Everyday Language	Age, Sex, Aβ (par^⋅)	0.09	None
Everyday Visuospatial	Age-, Tau(Braak I^, Braak III-IV^, Braak V-VI)	0.11	Age, Tau (Braak I^*)	0.07
Everyday Planning	Age^, Tau(Braak I^, Braak III-IV^, Braak V-VI^)	0.19	Age-, Tau (Braak I^*), APOE-Ɛ4	0.18
Everyday Organization	Aβ(par^*)	0.10	Tau (Braak III-IV^, Braak V-VI), Aβ (cing^, temp^*), APOE-Ɛ4	0.28
Everyday Divided Attention	Age-, APOE-Ɛ4 ^*	0.08	Tau(Braak III-IV^, Braak V-VI^), Sex^⋅	0.16

Blue Cells are models that included only Aβ with p<0.05.

Green cells are models that included only tau (p<0.05).

Red color present models that included both pathologies.

Significance codes: 0

^‘*’

0.05

^‘⋅’

0.1

^{‘ ‘}