Table 3.
Clinical characteristics of historic and current mAS clinical features
| Clinical Feature |
Le Fevre et al., 2017 Present/total (%) |
Carson and Duis, 2019 Present/total (%) |
p‐value |
|---|---|---|---|
| Word number | >10, 12/26 (46) | >20, 13/22 (59) | 0.18 |
| Age of onset walking (years) | 1.5 (range 1–3) | 1.7 (range 1–3) | |
| Walked by age 5 | 24/24 (100) | 22/22 (100) | a |
| Ataxia | 11/25 (44) | 6/21 (29) | 0.10 |
| Seizures | 8/28 (29) | 1/22 (5) | <0.0001 |
| Microcephaly | 3/26 (12) | 5/22 (23) | 0.16 |
| Abnormal EEG | 7/11 (64) | 7/16 (44) | 0.19 |
| Hypopigmentation | 2/11 (18) | 5/22 (23) | 0.70 |
| Obesity | 8/25 (32) | 14/22 (64) | 0.0009 |
| Hyperphagia | 11/20 (55) | 18/22 (82) (food seeking) | 0.0017 |
| Feeding problem | 7/24 (29) (Neonatal) | 2/22 (9) | 0.0006 |
| Behavioral problems | 4/5 (80) |
21/22 (95) anxiety 13/22 (59) hyperactivity |
0.12 |
| Sleeping Difficulties | 5/6 (83) | 16/22 (73) | 0.56 |
| Facial dysmorphic features | 3/9 (33) | 7/22 (32) | 0.93 |
a
Denotes inability to do chi‐square do to expected value of 0.