Table 4.
Univariate and multivariate analyses of recurrence
| Variable | Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Sex | ||||||
| Male | 1.000 | |||||
| Female | 2.661 | 0.801–8.839 | 0.110 | |||
| Operation type | ||||||
| TME | 1.000 | 1.000 | ||||
| TAE | 6.759 | 2.035–22.453 | 0.002 | 6.759 | 2.035–22.453 | 0.002 |
| Tumor size (cm) | ||||||
| <3 | 1.000 | |||||
| ≥3 | 0.841 | 0.179–3.965 | 0.830 | |||
| Distance from AV (cm) | ||||||
| <5 | 1.000 | |||||
| ≥5 | 0.386 | 0.116–1.282 | 0.560 | |||
| Depth of tumor | ||||||
| Shallow SM invasion | 1.000 | |||||
| Deep SM invasion | 2.839 | 0.622–12.959 | 0.180 | |||
| Histology | ||||||
| Favorable | 1.000 | |||||
| Unfavorable | 7.183 | 0.923–55.881 | 0.060 | |||
| Lymphovascular invasion | ||||||
| No | 1.000 | |||||
| Yes | 1.701 | 0.373–7.765 | 0.490 | |||
| CEA | ||||||
| Normal | 1.000 | |||||
| Elevated | 4.914 | 0.634–38.084 | 0.130 | |||
| Radiation therapy | ||||||
| No | 1.000 | |||||
| Yes | 2.883 | 0.780–10.659 | 0.110 | |||
| Chemotherapy | ||||||
| No | 1.000 | |||||
| Yes | 0.945 | 0.207–4.312 | 0.180 | |||
HR, hazard ratio; CI, confidence interval; TAE, transanal excision; TME, total mesorectal excision; AV, anal verge; SM, submucosal; CEA, carcinoembryonic antigen.