Table 5.
Univariate and multivariate analyses of local recurrence
| Variable | Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Sex | ||||||
| Male | 1.000 | |||||
| Female | 7.844 | 0.944–65.152 | 0.060 | |||
| Operation type | ||||||
| TME | 1.000 | 1.000 | ||||
| TAE | 20.788 | 2.503–172.686 | 0.005 | 19.066 | 2.274–159.832 | 0.007 |
| Tumor size (cm) | ||||||
| <3 | 1.000 | |||||
| ≥3 | 0.033 | 0.000–118.142 | 0.420 | |||
| Distance from AV (cm) | ||||||
| <5 | 1.000 | |||||
| ≥5 | 0.316 | 0.061–1.627 | 0.170 | |||
| Depth of tumor | ||||||
| Shallow SM invasion | 1.000 | |||||
| Deep SM inv. | 3.335 | 0.401–27.701 | 0.650 | |||
| Histology | ||||||
| Favorable | 1.000 | 1.000 | ||||
| Unfavorable | 12.110 | 1.455–100.790 | 0.021 | 6.846 | 0.808–57.976 | 0.080 |
| LVI | ||||||
| No | 1.000 | |||||
| Yes | 1.370 | 0.165–11.382 | 0.770 | |||
| CEA | ||||||
| Normal | 1.000 | |||||
| Elevated | 4.914 | 0.634–38.084 | 0.130 | |||
| Radiation therapy | ||||||
| No | 1.000 | |||||
| Yes | 1.468 | 0.177–12.196 | 0.720 | |||
| Chemotherapy | ||||||
| No | 1.000 | |||||
| Yes | 0.037 | 0.000–167.320 | 0.440 | |||
HR, hazard ratio; CI, confidence interval; TME, total mesorectal excision; TAE, transanal excision; AV, anal verge; SM, submucosal; LVI, lymphovascular invasion; CEA, carcinoembryonic antigen.