Figure 3.

CGX1321 Liposome Efficacies in LoVo Xenograft Mouse Model

(A) LoVo xenograft mice were treated with 10 mL/kg blank liposome, 1 mg/kg CGX1321 in liposome, or 10 mg/kg CGX1321 in liposome, i.v., q.o.d. for 14 days. The tumor volumes (mm³) were measured and plotted as mean with SEM (N = 8 per group), *p < 0.05. (B) Axin2 mRNA levels detected by qRT-PCR in vehicle and treatment groups 7 h after the last dose. Graphs represent mean with SEM (N = 4), *p < 0.05. (C) Representative images with H&E staining after 14 days of treatment. (D) Representative images of Alcian blue staining for mucin after 14 days of treatment.