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. 2019 Jul 5;27(9):1558–1567. doi: 10.1016/j.ymthe.2019.06.013

Figure 4.

Figure 4

Therapeutic Effects of CGX1321 Liposome Treatment in GA007 PDX Tumor

(A) LGR5 and β-catenin mRNA expression in GA007 by NanoString assay detection. (B) The tumor volumes (mm3) were measured and plotted as mean with SEM after CGX1321 liposome treatment for 16 days (N = 8 per group), **p < 0.01. (C) Axin2 mRNA levels in vehicle and treatment groups 7 h after final dosing, *p < 0.05. (D and E) H&E (D) and Alcian blue (E) staining of the tumor tissues. Tumor samples were from GA007 PDX mice, which were treated with 10 mL/kg liposome blank or 10 mg/kg CGX1321 in liposome, i.v., q.o.d. for 16 days.