Table 2.
ETV6-RUNX1 prediction values for CD9 percentage and MFI-r by flow cytometry.
| CD9 expression | ||
|---|---|---|
| Percentage | MFI | |
| All patients (n = 186) | ||
| Best cutoffa | 64% | 12.52 |
| Sensitivity | 99.0% | 72.0% |
| Specificity | 88.2% | 86.3% |
| Positive predictive value | 71.4% | 81.8% |
| Negative predictive value | 76.3% | 89.0% |
| Accuracy | 0.84 | 0.80 |
| Time to diagnosis | ||
| <24 h (n = 121) | ||
| Best cutoffa | 64% | 10.53 |
| Sensitivity | 96.0% | 70.0% |
| Specificity | 87.0% | 81.0% |
| Positive predictive value | 84.0% | 79.0% |
| Negative predictive value | 87.0% | 62.0% |
| Accuracy | 0.88 | 0.79 |
| Time to diagnosis | ||
| >24 h (n = 65) | ||
| Best cutoffa | 75% | 13.73 |
| Sensitivity | 28.0% | 50.0% |
| Specificity | 90.0% | 91.0% |
| Positive predictive value | 91.0% | 87.0% |
| Negative predictive value | 25.0% | 47.3% |
| Accuracy | 0.87 | 0.80 |
a
Best cutoff for maximizing CD9 expression sensitivity and specificity to predict ETV6-RUNX1; FISH: fluorescence in situ hybridization; MFI-r: median fluorescence intensity ratio.