Table 1.
Sensitivity and specificity of some screening tests used in the diagnosis of T. cruzi. infection.
| Assay | Sensitivity (95%IC) | Specificity (95%IC) | Manufacturer |
|---|---|---|---|
| EIA | |||
| HBK 401 Hemobio Chagas | 100 (97.9–100) | 99.62 (97.9–100) | Embrabio |
| Chagas ELISA | 97.62 (94.0–99.3) | 97.71 (95.1–99.2) | Ebram |
| Chagatek ELISA | 99.4 (96.7–100) | 99.24 (97.3–99.9) | Laboratório Lemos |
| Premier Chagas IgG ELISA Test | 94.04 (89.3–97.1) | 100 (98.6–100) | Meridian Diagnostics |
| ELISA test for Chagas | 99.4 (91.2–98.1) | 99.62 (97.9–100) | BIOSChile |
| Bioelisacruzi | 98.21 (94.9–99.6) | 99.24 (97.3–99.9) | Biolab-Mérieux |
| Abbott Chagas EIA Antibodies |
99.4 (96.2–100) | 98.09 (95.6–99.4) | Abbott Laboratories |
| Chagas test IICS, ELISA | 97.02 (93.2–99.0) | 99.24 (97.3–99.9) | ICC Univ. de Asunción |
| ELISA test for chagas | 98.81 (95.8–99.9) | 99.62 (97.9–100) | Wiener lab |
| Bioelisa Chagas | 100 (97.8–100) | 99.24 (97.3–99.9) | Biokit |
| Chagas Hemagen | 100 (97.8–100) | 96.56 (93.6–98.4) | Hemagen Diagnósticos |
| Hemagglutination | |||
| Chagas HAI Immunoserum | 97.62 (94.0–99.3) | 78.62 (77.2–83.4) | Polichaco |
| Teste Chagas-HAI | 88.09 (82.2–92.6) | 59.92 (53.7–65.9) | Ebram |
| Imuno-HAI Chagas | 100 (97.2–100) | 95.8 (92.6–97.9) | WAMA |
| Chagas Hemagen HA | 92.26 (87.1–95.8) | 89.31 (84.9–92.8) | Hemagen Diagnósticos |
| Hemacruzi | 99.4 (96.7–100) | 97.33 (94.6–98.9) | Biolab-Mérieux |
| Particle agglutination assays | |||
| Serodia-Chagas | 100 (97.2–100) | 97.7 (95.1–99.2) | Fujirebio |
| ID-Chagas antibody test | 97.02 (93.2–99.0) | 99.62 (97.9–100) | DiaMed-ID |
| Rapid tests | |||
| Chagas Stat-Pak | 94.08 (89.1–97.3) | 95.75 (92.1–98.0) | Chembio Diagnostic Systems |
| Confirmatory tests | |||
| RIPA | 100 (97.8–100) | 100 (98.6–100) | University of Iowa |
| WB | 100 (97.8–100) | 97.3 (94.6–98.9) | bioMérieux |
| IB | 98.2 (94.9–99.6) | 99.6 (97.9–100) | Innogenetics |
| IF | 98.2 (94.9–99.6) | 98.0 (96.7–99.8) | bioMérieux |