Fig. 1.

Stem cell-derived extracellular vesicles (SC-EVs) contribution to tissue repair. Stem cells release EVs that accumulate at the site of tissue injury and deliver proteins and specific patterns of mRNAs and microRNAs (miRNAs) to injured cells. When incorporated into damaged cells, SC-EVs activate regenerative programs, which accelerate tissue recovery and include cell dedifferentiation, cell cycle reentry, proliferation, and redifferentiation. Inset: representative transmission electron microscopy image of EVs (original magnification ×250,000).