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. 2019 May 29;317(2):R346–R354. doi: 10.1152/ajpregu.00084.2019

Table 1.

Muscle metabolic responses in Leg1CON, Leg1PL, Leg1ACT, Leg2CON, Leg2PL-CONTRA, and Leg2ACT-CONTRA conditions

Leg1CON Leg1PL Leg1ACT Leg2CON Leg2PL-CONTRA Leg2ACT-CONTRA
[PCr]
    Baseline, % 100 (0) 100 (0) 100 (0) 100 (0) 92 (5)* 93 (4)*
    120 s, % 70 (8) 70 (8) 71 (7) 71 (8) 62 (9)* 63 (7)*
    End exercise, % 42 (9) 41 (9) 41 (8) 44 (8) 45 (7) 44 (8)
    Rate of change, mmol/s −0.06 (0.01) −0.06 (0.03) −0.06 (0.02) −0.05 (0.03) −0.06 (0.04) −0.06 (0.03)
[Pi]
    Baseline, % 100 (0) 100 (0) 100 (0) 100 (0) 125 (24)* 126 (23)
    120 s, % 310 (66) 313 (71) 306 (62) 312 (66) 316 (70) 318 (64)
    End exercise, % 590 (149) 590 (137) 594 (156) 588 (177) 459 (110)* 460 (109)*
    Rate of change, mmol/s 0.05 (0.02) 0.05 (0.02) 0.05 (0.02) 0.05 (0.02) 0.05 (0.02) 0.05 (0.02)
[ADP]
    Baseline, % 100 (0) 100 (0) 100 (0) 100 (0) 200 (78)* 201 (77)*
    120 s, % 404 (161) 415 (183) 400 (148) 412 (170) 538 (176) 516 (154)*
    End-exercise, % 1,028 (386) 1,036 (421) 1,046 (409) 1,024 (401) 980 (316) 978 (312)
    Rate of change, µmol/s 0.15 (0.08) 0.15 (0.09) 0.14 (0.07) 0.15 (0.09) 0.17 (0.10) 0.15 (0.09)
pH
    Baseline 7.04 (0.01) 7.03 (0.02) 7.05 (0.04) 7.04 (0.03) 7.04 (0.03) 7.05 (0.02)
    120 s 6.96 (0.09) 6.94 (0.07) 6.92 (0.08) 6.95 (0.08) 6.93 (0.10) 6.94 (0.08)
    End-exercise 6.77 (0.18) 6.76 (0.15) 6.76 (0.16) 6.83 (0.15) 6.83 (0.20) 6.80 (0.15)

Values are means (SD) of 14 male subjects who performed single-leg severe-intensity knee-extensor exercise to task failure on the left (Leg1) and right (Leg2) legs without prior contralateral fatigue and on Leg2 immediately following Leg1 (Leg2-CONTRA). PL, placebo; ACT, acetaminophen; [PCr], phosphocreatine concentration; [Pi], Pi concentration; [ADP], ADP concentration.

*

P < 0.05 vs. Leg2CON.