Fig. 4.

Right ventricular systolic pressure (RVSP) is augmented in ASIC2^−/− mice. Summary data for RVSP (A) and ratio of right ventricular (RV) to left ventricular plus septum (LV + S) heart weight (B) in anesthetized wild-type (WT), acid-sensing ion channel (ASIC)2^−/−, and ASIC3^−/− mice following exposure control or chronic hypoxia (CH) conditions. Values are means ± SE; n/group are indicated at the bottom of the bars as no. of males/females and as color-coded dots: black circle, control male; red circle, control female; black square, CH male; red square, CH female. There is no significant difference between males and females (P = 0.62). ****P < 0.0001 vs. respective control (Con) and ####P < 0.0001 vs. corresponding WT, analyzed by 2-way ANOVA and individual groups compared using Tukey’s multiple-comparisons test.