Fig. 3.

Voiding behavior from high-fat diet (HFD)/streptozotocin (STZ) animals and age-matched control animals over a 6-mo period. A−C: proposed timeline of the compensated and decompensated states of the HFD/STZ model (A) based on volume per void (in ml; B) and number of voids over a 6-h period (C). The HFD/STZ group exhibited a significant increase in volume per void from 1 to 6 mo after STZ compared with both age-matched control and HFD groups (B). The number of voids over a 6-h period was significantly increased from 4 to 6 mo after STZ (C). Statistical comparisons were made using two-way repeated-measures ANOVA and a Bonferroni posttest. *P ≤ 0.05 compared with the control group; #P ≤ 0.05 compared with the HFD group; ϴP ≤ 0.05, HFD group compared with control group. Values are means ± SE of 12–20 animals from 1 wk before STZ to 4 mo after STZ and 3–7 animals from 5–6 mo after STZ. Measurements were taken 1 day per month for 1–6 mo.