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. 2019 May 29;317(2):F388–F398. doi: 10.1152/ajprenal.00178.2019

Fig. 6.

Fig. 6.

Maximal force changes to exogenous addition of ATP and carbachol over disease progression in the high-fat diet (HFD)/streptozotocin (STZ) and age-matched control groups from 1 to 6 mo. To determine changes in maximal force over disease progression in either the HFD/STZ or age-matched control group, 1, 3, and 6 mo after STZ, ATP- and carbachol-induced force were compared. A and B: exogenous additions of ATP-induced force over disease progression in age-matched control (A) and HFD/STZ (B) urinary bladder smooth muscles. ATP-induced force did not change over disease progression in either the HFD/STZ or age-matched control groups. C and D: exogenous additions of carbachol-induced force over disease progression in age-matched control (C) and HFD/STZ (D) urinary bladder smooth muscles. Carbachol-induced force in the control group did not change over disease progression; however, carbachol-induced force in the HFD/STZ group was significantly changed. Bladder smooth muscle force from 3 mo after STZ was significantly increased over 1 mo after STZ. Force between 1 and 6 mo after STZ injections was not significantly different within the HFD/STZ group. Statistical comparisons were made using two-way repeated-measures ANOVA and a Bonferroni posttest. *P ≤ 0.05.