Table 1.

Characteristics of the compensated and decompensated states of diabetic bladder dysfunction in the high-fat diet/STZ rat model

	Compensated State	Decompensated State
Description	Storage problems	Voiding problems
Start	After STZ injections	4 mo after STZ injections
Characteristics
Plasma glucose	↑	↑
Urine volume per void	↑	↑
Number of voids	↔	↑
Body weight	↔	↓
Bladder wet weight	↑	↑
Smooth muscle thickness	↑	↑
Smooth muscle ratio	↑	↔
Detrusor muscle changes
ATP-induced force	↑	↑
Carbachol-induced force	↑	↔
M3 receptor expression	↔	↑

STZ, streptozotocin; ↑, increase; ↔, no change; ↓, decrease.