Fig. 8.
PIEZO1-tandem-dimer Tomato (tdT) expression in the mouse urethra. A–D: distribution of PIEZO1-tdT in the female urethra (A), female rhabdosphincter (B), female vaginal epithelium (C), or male urethra (D) in Piezo1tdT/tdT and Piezo1+/+ mice. Examples of blood vessels are marked with yellow arrows, and the position of the apicolateral junctional complex is marked with white arrows. The insets in A show the localization of PIEZO1-tdT along the basolateral membranes of surface-localized epithelial cells and the surfaces of the underlying cell layers. The insets in B show that PIEZO1-tdT was expressed by skeletal muscle cells in the rhabdosphincter. The insets in C show the localization of PIEZO1-tdT within the epithelium lining the vagina. The insets in D show the localization of PIEZO1-tdT within the epithelium lining the male urethra. Nuc, nuclei.