Fig. 11.

Na⁺-dicarboxylate cotransporter 1 (NaDC1) immunohistochemistry in response to hypokalemia in Na⁺-coupled electrogenic bicarbonate cotransporter A variant (NBCe1-A) knockout (KO) mice. Top and middle: NaDC1 immunohistochemistry in NBCe1-A KO mice on the K⁺control diet (top) and after the K⁺-free diet (middle) for 4 days. Bottom: results of quantitative immunohistochemistry for NaDC1 immunolabel. Results are normalized to mean proximal convoluted tubule (PCT) expression in wild-type (WT) mice on the K⁺ control diet equal to 100.0. The K⁺-free diet did not alter NaDC1 expression significantly in either the PCT, proximal straight tubules in the medullary ray (PST-MR), or proximal straight tubules in the in the outer medulla (PST-OM). Results are from 5 mice on the K⁺ control diet and 6 mice on the K⁺-free diet. *Proximal tubule.