Obeticholic acid (OCA) affects cecal bile acids disparately in pregnant (D18) and nonpregnant (D0) mice. Cecal concentrations of total bile acids (A), total primary bile acids (B), total secondary bile acids (C), and individual bile acid species (D–E) in D0 and D18 mice are shown; n = 5–6 mice per group. *P < 0.05 vs. normal chow (NC), #P < 0.05 vs. high-fat diet (HFD), as determined by one-way ANOVA followed by Tukey’s multiple comparisons test. a/b/oMCA, α/β/ω-muricholic acid; CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; UDCA, ursodeoxycholic acid; LCA, lithocholic acid; HDCA, hyodeoxycholic acid; T, taurine; TCA, taurocholic acid.