Fig. 1.

Means ± SE (n, number of rats) and individual data showing that statically contracting the hindlimb muscles evoked an exaggerated peak pressor response in the 31-wk compared with the responses in 21-wk T2DM and nondiabetic rats (A). Peak changes in heart rate were not different among the groups (B). Developed tensions [tension-time index (TTI)] were similar among groups (C). *P < 0.05 (1-way ANOVA) indicates statistically greater response compared with nondiabetic rats. #P < 0.05 (1-way ANOVA) indicates statistically greater pressor response compared with 21-wk type-2 diabetes mellitus (T2DM) rats. MAP, mean arterial pressure; HR, heart rate; bpm, beats/min,