Table 4.
IPA Category | Gene Symbol | Gene Name |
---|---|---|
Inflammatory signaling |
CCR2 COL5A3 TNFRSF12A CCL11 SELE |
Chemokine (C-C motif) receptor 2 Collagen, type V, α3 Tumor necrosis factor receptor superfamily, member 12a Chemokine (C-C motif) ligand 11 Selectin E |
Circadian rhythm signaling |
PER3 PER2 GRIN2C |
Period circadian regulator 3 Period circadian regulator 2 Glutamate receptor, ionotropic, NMDA2C (ε3) |
Leukocyte extravasation signaling |
ITGAL BMX TIMP4 RASGRP1 |
Integrin αL BMX nonreceptor tyrosine kinase Tissue inhibitor of metalloproteinase 4 RAS guanyl-releasing protein 1 |
Most representative canonical pathways deregulated in mice exposed to electronic cigarettes (2.4%). We have added blue arrows pointing to genes associated with the IPA analysis in Fig. 2A. IPA, Ingenuity Pathway Analysis.