Table 4.

Canonical pathways tested by IPA

IPA Category	Gene Symbol	Gene Name
Inflammatory signaling	CCR2 COL5A3 TNFRSF12A CCL11 SELE	Chemokine (C-C motif) receptor 2 Collagen, type V, α3 Tumor necrosis factor receptor superfamily, member 12a Chemokine (C-C motif) ligand 11 Selectin E
Circadian rhythm signaling	PER3 PER2 GRIN2C	Period circadian regulator 3 Period circadian regulator 2 Glutamate receptor, ionotropic, NMDA2C (ε3)
Leukocyte extravasation signaling	ITGAL BMX TIMP4 RASGRP1	Integrin αL BMX nonreceptor tyrosine kinase Tissue inhibitor of metalloproteinase 4 RAS guanyl-releasing protein 1

Most representative canonical pathways deregulated in mice exposed to electronic cigarettes (2.4%). We have added blue arrows pointing to genes associated with the IPA analysis in Fig. 2A. IPA, Ingenuity Pathway Analysis.