Table 3.
The relationship between coagulative biomarkers and AKI according to multivariable logistic regression analysis
| Coagulative biomarkers | AKI Median (IQR) | Non-AKI Median (IQR) | Unadjusted OR (95% CI) | p-value | Adjusted: model 1 OR (95% CI) |
p-value | Adjusted: model 2 OR (95% CI) |
p-value |
|---|---|---|---|---|---|---|---|---|
| APTT | 49.5 (42.3–60.9) | 44.3 (37.2–49.6) | 1.050 (1.018–1.083) | 0.002 | 1.074 (1.030–1.120) | 0.001 | 1.074 (1.032–1.118) | <0.001 |
| PT | 18.5 (16.1–23.2) | 17.2 (15.5–19.3) | 1.115 (1.031–1.206) | 0.007 | 1.162 (1.037–1.302) | 0.010 | 1.168 (1.052–1.298) | 0.004 |
| INR | 1.53 (1.30–2.0) | 1.41 (1.28–1.66) | 2.571 (1.209–5.470) | 0.014 | 3.923 (1.322–11.640) | 0.014 | - | - |
| D-dimer | 3770.0 (2445.0–9130.0) | 2810.0 (723.5–5095.0) | 1.108 (1.024–1.198) | 0.011 | 1.098 (1.002–1.202) | 0.045 | 1.096 (1.003–1.197) | 0.042 |
| Fg | 3.2 (2.5–4.5) | 3.4 (1.7–4.8) | 0.924 (0.788–1.085) | 0.336 | - | - | - | - |
| PLT | 106.0 (67.5–141.5) | 124.0 (80.5–172.0) | 0.995 (0.989–1.000) | 0.046 | 1.001 (0.994–1.009) | 0.752 | 0.996 (0.989–1.003) | 0.262 |
Notes: Model 1 included age, sex, hypertension, CCI, PCT, NT-proBNP, Lac and SOFA score; Model 2 included age, sex, hypertension, CCI, PCT, NT-proBNP, Lac and APACHE II score.
Abbreviations: APTT, activated partial thromboplastin time; PT, prothrombin time; INR, international normalized ratio; Fg, plasma fibrinogen; PLT, platelet; CCI, Charlson Comorbidity Index; PCT, serum procalcitonin; NT-proBNP, serum N-Terminal pro-brain natriuretic peptide; Lac, serum lactate; SOFA score, Sequential Organ Failure Assessment score; APACHE II score, Acute Physiology and Chronic Health Evaluation II score.