Table 4.
The AUC of coagulative biomarkers for predicting AKI after adjustment for baseline characteristics in model 1 or model 2
| Coagulative biomarkers | AUC | 95% CI | Sensitivity (%) | Specificity (%) | Youden Index |
|---|---|---|---|---|---|
| Adjusted: model 1 | |||||
| APTT | 0.857 | 0.797–0.918 | 76.9 | 80.8 | 0.577 |
| PT | 0.832 | 0.765–0.898 | 78.5 | 72.6 | 0.511 |
| D-dimer | 0.844 | 0.780–0.909 | 83.1 | 75.3 | 0.584 |
| INR | 0.828 | 0.761–0.895 | 83.1 | 69.9 | 0.530 |
| Adjusted: model 2 | |||||
| APTT | 0.848 | 0.784–0.912 | 69.2 | 89.0 | 0.582 |
| PT | 0.826 | 0.757–0.894 | 75.4 | 79.5 | 0.549 |
| D-dimer | 0.820 | 0.749–0.892 | 81.5 | 75.3 | 0.568 |
Notes: Model 1 included age, sex, hypertension, CCI, PCT, NT-proBNP, Lac and SOFA score; Model 2 included age, sex, hypertension, CCI, PCT, NT-proBNP, Lac and APACHE II score.
Abbreviations: APTT, activated partial thromboplastin time; PT, prothrombin time; INR, international normalized ratio; CCI, Charlson Comorbidity Index; PCT, serum procalcitonin; NT-proBNP, serum N-Terminal pro-brain natriuretic peptide; Lac, serum lactate; SOFA score, Sequential Organ Failure Assessment score; APACHE II score, Acute Physiology and Chronic Health Evaluation II score.