Table 5.
Multivariate Cox regression analysis for 30-day mortality
| Coagulative biomarkers | Survivors Median (IQR) | Nonsurvivors Median (IQR) | Unadjusted OR (95% CI) | p-value | Adjusted: model 1 OR (95% CI) |
p-value | Adjusted: model 2 OR (95% CI) |
p-value |
|---|---|---|---|---|---|---|---|---|
| APTT | 44.9 (39.0–50.9) | 51.0 (43.7–64.0) | 1.044 (1.015–1.074) | 0.003 | 1.065 (1.025–1.107) | 0.001 | 1.061 (1.023–1.102) | 0.002 |
| PT | 17.2 (15.5–19.6) | 18.7 (16.1–23.1) | 1.058 (0.993–1.127) | 0.083 | - | - | - | - |
| INR | 1.5 (1.3–1.7) | 1.6 (1.3–2.0) | 1.852 (0.982–3.493) | 0.057 | - | - | - | - |
| D-dimer | 3345.0 (947.5–6097.5) | 3245.0 (2252.5–7780.0) | 1.017 (0.944–1.095) | 0.663 | - | - | - | - |
| Fg | 3.5 (2.6–5.0) | 3.1 (1.6–3.8) | 0.809 (0.649–1.008) | 0.059 | - | - | - | - |
| PLT | 131.0 (88.8–165.3) | 91.5 (49.3–132.8) | 0.990 (0.983–0.997) | 0.003 | 0.995 (0.987–1.004) | 0.293 | 0.990 (0.981–0.998) | 0.016 |
Notes: Model 1 included age, sex, hypertension, CCI, PCT, NT-proBNP, Lac and SOFA score; Model 2 included age, sex, hypertension, CCI, PCT, NT-proBNP, Lac and APACHE II score.
Abbreviations: APTT, activated partial thromboplastin time; PT, prothrombin time; INR, international normalized ratio; PLT, platelet; CCI, Charlson Comorbidity Index; PCT, serum procalcitonin; NT-proBNP, serum N-Terminal pro-brain natriuretic peptide; Lac, serum lactate; SOFA score, Sequential Organ Failure Assessment score; APACHE II score, Acute Physiology and Chronic Health Evaluation II score.