Table 1.

Dosing regimen for eculizumab in patients with atypical hemolytic uremic syndrome

		Induction dose	Maintenance dose
Dose in patients 18 years or older		900 mg once a week for 4 weeks	1200 mg in week 5 after induction dose is completed. Followed by 1200 mg once every 2 weeks
Dose in patients <18 years	Weight >40 kg	900 mg once a week for 4 weeks	1200 mg in week 5 after induction dose is completed. Followed by 1200 mg every 2 weeks.
	30–40 kg	600 mg once a week for 2 weeks	900 mg in week 3 after induction dose is completed. Followed by 900 mg every 2 weeks.
	20–30 kg	600 mg once a week for 2 weeks	600 mg in week 3 after induction dose is completed. Followed by 600 mg every 2 weeks.
	10–20 kg	600 mg in week 1	300 mg in week 2. 300 mg every 3 weeks.
5–10 kg	300 mg in week 1	300 mg in week 2. 300 mg every 3 weeks.

Note: Data from Soliris (Eculizumab) highlights of prescribing information. US Food and Drug Administration. 2007. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/125166s172lbl.pdf.36