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. 2019 Sep 4;14:7191–7213. doi: 10.2147/IJN.S213836

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© 2019 Abd El Hady et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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X-ray diffractometry.

Notes: (A) Uncoated diosmin-PLGA nanoparticles (F5). (I) Diosmin, (II) PLGA, (III) diosmin:PLGA 1:1 PM, (IV) plain uncoated nanoparticles, and (V) medicated uncoated PLGA nanoparticles. (B) Chitosan-coated PLGA nanoparticles (F14). (I) Diosmin, (II) PLGA, (III) chitosan, (IV) diosmin:chitosan 1:1 PM, (V) plain chitosan-coated nanoparticles, and (VI) medicated chitosan-coated nanoparticles.

Abbreviations: PLGA, poly (d,l-lactide-co-glycolide); PM, physical mixture.