Table 4.
Prescription pattern by the drug classes, either included in monotherapy or combination therapy, n (%).
| ARB | ACEI | BETA | CCB | Diuretics | |
|---|---|---|---|---|---|
| Overall | 150,6561 (51.61) | 90,784 (3.11) | 539,372 (18.48) | 1,314,597 (45.03) | 496,634 (17.01) |
| Age (mean ± SD) | 53.01 ± 12.74 | 53.4 ± 17.74 | 51.43 ± 16.17 | 54.32 ± 13.73 | 54.07 ± 13.81 |
| <20 | 6,928 (15.32) | 5,564 (12.30) | 15,015 (33.20) | 7,479 (16.54) | 3,092 (6.84) |
| 20–29 | 31,458 (32.94) | 2,561 (2.68) | 35,064 (36.72) | 32,134 (33.65) | 13,038 (13.65) |
| 30–39 | 156,422 (51.54) | 7,447 (2.45) | 66,968 (22.06) | 130,704 (43.06) | 48,151 (15.86) |
| 40–49 | 415,900 (58.29) | 17,660 (2.48) | 118,228 (16.57) | 315,763 (44.25) | 124,418 (17.44) |
| 50–59 | 476,338 (54.98) | 24,123 (2.78) | 142,677 (16.47) | 393,807 (45.45) | 148,443 (17.13) |
| 60–69 | 251,389 (49.42) | 17,004 (3.34) | 87,818 (17.26) | 241,238 (47.43) | 86,640 (17.03) |
| 70–79 | 131,138 (44.49) | 11,737 (3.98) | 55,469 (18.82) | 145,191 (49.26) | 54,624 (18.53) |
| ≥80 | 36,988 (40.38) | 4,688 (5.12) | 18,133 (19.80) | 48,281 (52.71) | 18,228 (19.90) |
| Sex | |||||
| Male | 904,778 (55.38) | 60,192 (3.68) | 275,763 (16.88) | 775,090 (47.44) | 251,286 (15.38) |
| Female | 601,783 (46.82) | 30,592 (2.38) | 263,609 (20.51) | 539,507 (41.97) | 245,348 (19.09) |
| Income | |||||
| Medical aid | 46,315 (41.27) | 3,943 (3.51) | 27,160 (24.20) | 46,751 (41.66) | 19,055 (16.98) |
| Q1 (low) | 398,887 (52.05) | 22,550 (2.94) | 139,374 (18.19) | 353,498 (46.13) | 138,079 (18.02) |
| Q2 | 363,159 (52.13) | 20,640 (2.96) | 126,485 (18.16) | 315,653 (45.31) | 121,217 (17.40) |
| Q3 | 346,565 (52.23) | 21,268 (3.21) | 119,086 (17.95) | 299,447 (45.13) | 111,549 (16.81) |
| Q4 (high) | 351,635 (51.68) | 22,383 (3.29) | 127,267 (18.7) | 299,248 (43.98) | 106,734 (15.69) |
| Residence | |||||
| Metropolitan | 909,496 (52.23) | 53,311 (3.06) | 320,725 (18.42) | 778,121 (44.69) | 282,095 (16.20) |
| City | 430,908 (51.68) | 25,320 (3.04) | 156,480 (18.77) | 375,042 (44.98) | 148,404 (17.80) |
| Rural | 166,157 (48.29) | 12,153 (3.53) | 62,167 (18.07) | 161,434 (46.92) | 66,135 (19.22) |
| Charlson comorbidity index | |||||
| 0 | 502,861 (53.60) | 12,245 (1.31) | 137,490 (14.66) | 456,193 (48.63) | 163,131 (17.39) |
| 1 | 411,171 (51.96) | 18,536 (2.34) | 136,449 (17.24) | 355,466 (44.92) | 138,614 (17.52) |
| 2 | 252,680 (50.79) | 19,096 (3.84) | 97,293 (19.56) | 212,683 (42.75) | 85,095 (17.10) |
| ≥3 | 339,849 (49.10) | 40,907 (5.91) | 168,140 (24.29) | 290,255 (41.94) | 109,794 (15.86) |
| Comorbidity | |||||
| Diabetes | 240,501 (64.74) | 21,283 (5.73) | 53,265 (14.34) | 127,538 (34.33) | 55,124 (14.84) |
| Dyslipidemia | 465,523 (57.74) | 44,577 (5.53) | 155,768 (19.32) | 331,832 (41.16) | 124,074 (15.39) |
| Congestive heart failure | 45,540 (37.71) | 22,783 (18.87) | 65,416 (54.18) | 37,246 (30.85) | 16,936 (14.03) |
| Ischemic heart failure | 148,348 (36.94) | 40,612 (10.11) | 161,776 (40.29) | 178,876 (44.55) | 44,121 (10.99) |
| Stroke | 67,621 (49.88) | 6,568 (4.84) | 34,636 (25.55) | 66,925 (49.37) | 19,360 (14.28) |
| Chronic kidney disease | 16,310 (59.82) | 2,274 (8.34) | 5,974 (21.91) | 12,220 (44.82) | 3,257 (11.95) |
| Cancer | 13,353 (29.92) | 1,531 (3.43) | 11,312 (25.35) | 24,520 (54.95) | 4,385 (9.83) |
| Provider type | |||||
| General hospital | 350,910 (37.95) | 67,357 (7.29) | 316,088 (34.19) | 406,074 (43.92) | 81,064 (8.77) |
| Hospital | 161,403 (48.77) | 5,958 (1.80) | 57,090 (17.25) | 176,623 (53.37) | 55,586 (16.80) |
| Clinic | 946,054 (60.62) | 14,843 (0.95) | 160,542 (10.29) | 668,985 (42.86) | 339,547 (21.76) |
| Others | 48,194 (46.82) | 2,626 (2.55) | 5,652 (5.49) | 62,915 (61.12) | 20,437 (19.85) |
| Year | |||||
| 2011 | 312,074 (49.75) | 21,853 (3.48) | 115,374 (18.39) | 291,626 (46.49) | 132,317 (21.09) |
| 2012 | 306,353 (51.24) | 20,206 (3.38) | 112,748 (18.86) | 257,977 (43.15) | 117,653 (19.68) |
| 2013 | 300,076 (51.87) | 18,703 (3.23) | 104,476 (18.06) | 252,941 (43.73) | 94,175 (16.28) |
| 2014 | 280,036 (52.01) | 15,514 (2.88) | 101,408 (18.83) | 245,769 (45.64) | 76,045 (14.12) |
| 2015 | 308,022 (53.38) | 14,508 (2.51) | 105,366 (18.26) | 266,284 (46.15) | 76,444 (13.25) |