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. 2019 Mar 5;316(6):E1118–E1135. doi: 10.1152/ajpendo.00496.2018

Fig. 12.

Fig. 12.

A: proposed model of extracellular matrix (ECM)-integrin-integrin-linked kinase (ILK) signaling and contributions to hepatic metabolism and glucoregulatory functions. B: model of altered hepatocyte metabolism and glucoregulatory functions upon disruption of integrin signaling via hepILK-knockout (KO). FGF21, fibroblast growth factor 21.