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. 2019 Sep 3;14:2003–2013. doi: 10.2147/COPD.S210897

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© 2019 Tavakoli et al.

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Trends in the percent of users on combination therapies (left), and (right*) average medication possession ratio per patient-year from 1997 to 2015.

Notes: *Numbers in brackets in the legend of the right panel give the average change between consecutive years. The baseline year for the trend is the first year of the medication’s presence in BC: 1997 for ICS, SABA, SAMA, LABA, and SAMA/SABA, 1999 for ICS/LABA, 2002 for LAMA, 2013 for LAMA/LABA (which is not presented in the figure due to the short duration).

Abbreviations: ICS, inhaled corticosteroids; LABA, long-acting beta-2 adrenoceptor agonists; LAMA, and long-acting muscarinic agents; ICS/LABA/LAMA, triple therapy.