. 2019 Sep 5;5(9):e02374. doi: 10.1016/j.heliyon.2019.e02374

Table 4.

ANOVA of the central composite design.

Source	Sum of Squares	df	Mean Square	F-Value	p-Value	Significance
Model	0.1200	9	0.0140	19.1800	<0.0001	**
A	0.0100	1	0.0100	14.7400	0.0033	**
B	0.0046	1	0.0046	6.4500	0.0294	*
C	0.0063	1	0.0063	8.9200	0.0137	*
AB	0.0091	1	0.0091	12.8700	0.0049	**
AC	0.0180	1	0.0180	26.0300	0.0005	**
BC	0.0012	1	0.0012	1.5900	0.2357
A²	0.0450	1	0.0450	63.8300	<0.0001	**
B²	0.0078	1	0.0078	11.0500	0.0077	**
C²	0.0310	1	0.0310	43.6200	<0.0001	**
Residual	0.0071	10	0.0007
Lack of Fit	0.0046	5	0.0009	1.79	0.2685
Pure Error	0.0026	5	0.0005
Cor Total	0.1300	19
R²	0.9452
R²_Adj	0.8960