Fig. 6.

A: body weight of Dahl salt-sensitive (SS) animals that received either PBS-containing liposomes (PBS-Lipo), clodronate (Clod) alone, or Clod-containing liposomes (Clod-Lipo) on days −3, 4, 11, and 18 of the 21-day 4.0% NaCl chow protocol. B: relative total kidney weight and spleen weight to body weight at the end of the experiment. C: Na⁺ excretion when rats were fed a 0.4% NaCl diet and weekly during the 4.0% NaCl period. D: K⁺ excretion when rats were fed the 0.4% NaCl diet and weekly during the 4.0% NaCl period. n = 11 for PBS-Lipo treatment, 5 for Clod treatmen, and 8 for Clod-Lipo treatment. Two-way repeated-measures ANOVA with a Holm-Sidak post hoc test was used for A, C, and D. One-way ANOVA was used in B. ***P < 0.001, **P < 0.01, and *P < 0.05 vs. PBS Lipo; ###P < 0.001 vs. Clod.