Figure 2.

Plasma electrolyte abnormalities in mut+ patients develop over time. Shown are box plots for the plasma concentrations of (a) magnesium (Mg), (b) potassium (K), (c) chloride (Cl), and (d) bicarbonate (TCO2) according to the 4 age groups. Box plot graphs represent the median and interquartile range (IQR); the upper and lower whiskers include data points within 1.5 × IQR. Outliers are plotted individually. The blue boxes represent the mut− group, and the red boxes represent mut+. The respective normal range is represented by the transparent blue boxes. Note the development with increasing age of a Gitelman-like tubulopathy with hypomagnesemia and hypokalemic, hypochloremic metabolic alkalosis in the mut+ group. For number of patients for each plot and results of statistical comparisons, see Table 1.