Table 1.
Exercised mdx study data
| Untreated mdx males Mean ± SEM (n) |
LS treated mdx males Mean ± SEM (n) |
Student’s t-test P-value |
|
|---|---|---|---|
| Body Weight (BW, g) | 26.4±0.7 (12) | 26.7±0.8 (12) | 0.8092 |
| Grip Strength (GS) - 6 w (N) | 1.5±0.07 (12) | 1.5±0.10 (12) | 0.6775 |
| GS -10 w (N) | 2.2±0.1 (12) | 2.2±0.3 (12) | 0.8156 |
| GS/BW - 6 w (mN/g) | 72.7±3.5 (12) | 67.9±5.0 (12) | 0.4379 |
| GS/BW - 10 w (mN/g) | 83.1±3.5 (12) | 83.3±8.7 (12) | 0.9831 |
| Δ GS Exerc (mN/g) | 10.4±4.2 (12) | 15.4±10.6 (12) | 0.6620 |
| Heart Weight (HW, g) | 0.15±0.005 (12) | 0.16±0.005 (12) | 0.7244 |
| HW/BW (mg/g) | 5.8±0.2 (12) | 5.8±0.1 (12) | 0.8956 |
| Heart Rate (bpm) | 592±16 (12) | 610±22 (12) | 0.5333 |
| QT (ms) | 50.3±0.8 (12) | 50.1±0.9 (12) | 0.8915 |
| QTc (ms) | 47.0±4.0 (12) | 38.5±2.5 (12) | 0.1014 |
| Dia specific force (mN/mm−2) | 107±17.9 (12) | 111±9.6(11) | 0.8487 |
| Dia fatigue (force fraction)* | 0.27±0.03 (12) | 0.28±0.03 (11) | 0.8232 |
| Dia abs recov (mN/mm−2)** | 13.0±2.8 (12) | 14.4±1.6 (11) | 0.6832 |
| Dia rel recov (%) | 71.3±8.4 (12) | 69.7±4.5 (11) | 0.8634 |
| EDL specific force (mN/mm−2) | 336±58 (7) | 355±35 (9) | 0.7709 |
| TA IgG (% CSA) | 10±4.0 (12) | 4±1.1 (12) | 0.1201 |
| TA CD11B (% CSA) | 6.2±1.2 (12) | 7.2±0.8 (11) | 0.5098 |
| Quad IgG (% CSA) | 7±2 (12) | 14±4 (12) | 0.0932 |
| Dia Fibronectin (% CSA) | 11±1.1 (12) | 10±1.0 (12) | 0.8746 |
| Centrally nucleated quad fibers (%) | 70.8±2 (11) | 70.5±1.2 (12) | 0.8924 |
Grip strength (GS); body weight (BW); heart weight (HW); heart rate (HR); QT interval (QT); QT adjusted for heart rate variability (QTc); diaphragm (Dia); extensor digitorum longus (EDL); tibiallis anterior (TA); quadriceps (quad).
*
Fraction of force left after 2 fatigue protocols, calculated by force at end of second protocol divided by force at beginning of first protocol.
**
Recovery of absolute force between end of the first fatigue protocol to beginning of the second protocol.