Table 2.
Aged mdx study data
| Control C57 males Mean ± SEM (n) |
Untreated mdx males Mean ± SEM (n) |
LS treated mdx males Mean ± SEM (n) |
P-value | ||
|---|---|---|---|---|---|
| ANOVA | Dunnett Untreat vs LS | ||||
| Body Weight (g) | 30.6±1.4 (15) | 33.0±0.7 (18) | 31.7±0.9 (18) | 0.2378 | 0.5007 |
| Exhaustion Running (m) | 870.6±189.1 (6) | 270.6±25.1 (6) | 262.1±46.9 (6) | 0.0022 | 0.9979 |
| GS Trial 1 (N) | 1.4±0.06 (14) | 0.9±0.03 (18) | 0.9±0.05 (18) | <0.0001 | 0.9789 |
| GS Trial 5 (N) | 1.4±0.05 (14) | 0.86±0.03 (18) | 0.87±0.04 (18) | <0.0001 | 0.9816 |
| GS/BW trial 1 (mN/g) | 50.9±2.5 (14) | 28.7±1.2(18) | 30.1±1.1 (18) | <0.0001 | 0.7519 |
| GS/BW trial 5 (mN/g) | 49.2±2.5 (14) | 26.9±0.9 (18) | 27.2±1.0 (18) | <0.0001 | 0.9779 |
| Heart Weight (g) | 0.14±0.007 (15) | 0.14±0.003 (18) | 0.14±0.01 (18) | 0.7038 | 0.6194 |
| HW/BW (mg/g) | 4.6±0.1 (15) | 4.3±0.1 (18) | 4.6±0.4 (18) | 0.7077 | 0.6641 |
| HR (bpm) | 730±12.9 (8) | 735±7.2 (16) | 731±10.3 (15) | 0.9270 | 0.9430 |
| QT (ms) | 44.2±1.5 (8) | 42.6±0.7 (16) | 44.2±0.8 (15) | 0.3255 | 0.2992 |
| QTc (ms) | 48.2±1.2 (8) | 47.0±0.7 (16) | 48.7±0.7 (15) | 0.2673 | 0.1995 |
| Ejection fraction (%) | 43.4±1.8 (8) | 59.8±2.5 (8) | 57.8±2.7 (8) | 0.0001 | 0.7686 |
| Dia spec. force (mN/mm−2) | 150±20.4 (13) | 102±7.5 (16) | 98±9.2(15) | 0.0123 | 0.9493 |
| Dia fatigue (force fraction)* | 0.28±0.03 (14) | 0.36±0.02(18) | 0.32±0.02(14) | 0.0521 | 0.3461 |
| Dia abs recov (mN/mm−2)** | 17±3.3 (14) | 8±0.9 (18) | 9±1.5 (14) | 0.0035 | 0.8511 |
| Dia rel recov (%) | 60±7.0(14) | 45±3.0(18) | 47±4.0(14) | 0.0457 | 0.8958 |
| EDL specific force (mN/mm−2) | 336±17 (14) | 284±13 (18) | 261±16 (18) | 0.0056 | 0.4526 |
| ECC1 (mN/mm−2) | 323±24 (15) | 269±15 (18) | 250±14 (17) | 0.0209 | 0.6594 |
| ECC2 (% Ecc1) | 94±2 (15) | 87±3 (18) | 90±1.5 (17) | 0.0363 | 0.3066 |
| ECC5 (% Ecc1) | 79±5 (15) | 62±6 (18) | 73±3 (17) | 0.0459 | 0.1713 |
| Post-rest ecc6/ecc1 (% tet) | 82±5 (15) | 64±6 (18) | 75±3 (17) | 0.0348 | 0.1843 |
| Quad IgG (# Fibers) | 2±1 (7) | 18±5 (9) | 23±7 (12) | 0.0779 | 0.8387 |
| Dia Coll (% CSA) | 25±2.0 (15) | 59±2 (18) | 55±3 (18) | <0.0001 | 0.2688 |
Grip strength (GS); body weight (BW); heart weight (HW); heart rate (HR); QT interval (QT); QT adjusted for heart rate variability (QTc); diaphragm (Dia); extensor digitorum longus (EDL); EDL force after eccentric contraction (ECC); quadriceps (quad).
*
Fraction of force left after 2 fatigue protocols, calculated by force at end of second protocol divided by force at beginning of first protocol.
**
Recovery of absolute force between end of the first fatigue protocol to beginning of the second protocol.