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. Author manuscript; available in PMC: 2019 Sep 9.
Published in final edited form as: J Mol Cell Cardiol. 2018 Jul 5;121:107–123. doi: 10.1016/j.yjmcc.2018.07.003

Fig. 7.

Fig. 7.

TRAF3IP2 gene deletion blunts TWEAK-induced myocardial fibrosis. Both wild type and TRAF3IP2-KO mice were continuously infused with TWEAK (10 μg/kg body weight/day) for 7 days via subcutaneously implanted osmotic minipumps (A). Cardiac fibrosis was analyzed by Masson’s trichrome (B; quantitative measurement of fibrosis is shown on the right), collagen Iα1 and collagen IIIα1 mRNA expression (RT-qPCR; C), and collagen and fibronectin protein expression (immunoblotting; D) in WT mice, and TRAF3IP2 gene ablation blunted these TWEAK-induced pro-fibrotic responses. While the immunoblots in D show three individual animals selected at random in each group, the corresponding summarized semi-quantification data in panel E includes all 5 animals/group. C, E, *P < 0.05 versus untreated, †P < 0.05 versus TWEAK (n = 5/group).