Table 3.
Successful versus failed testicular sperm extraction in 225 men with history of cryptorchidism
| Phenotypic characteristics | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| Positive sperm retrieval (n=144) | Negative sperm retrieval (n=81) | P | Odds ratio (95% CI) | P | |
| Age at TESE (year), median (5th–95th centiles) | 31 (25–42) | 32 (26–42) | 0.628 | ||
| Age at orchidopexya, median (5th–95th centiles) | 9 (4–17) | 10 (5–25) | 0.036 | ||
| Smokingb, n/total number (%) | 57/144 (39.6) | 28/80 (35.0) | 0.498 | ||
| Bilateral (reference) versus unilateral, n/total number (%) | 96/144 (66.7) | 49/81 (60.5) | 0.353 | ||
| FSH levels (IU l−1), median (5th–95th centiles) | 19.2 (5.2–49.9) | 23.6 (11.5–56.1) | 0.007 | ||
| Inhibin B levels (pg ml−1)c, median (5th–95th centiles) | 40 (14–167) | 36 (12–117) | 0.328 | ||
| Undetectable inhibin B leveld, n/total number (%) | 40/117 (34.2) | 36/68 (52.9) | 0.012 | 0.502 (0.279–0.905) | 0.022 |
| Testosterone levels (ng ml−1), median (5th–95th centiles) | 3.96 (2.16–6.86) | 3.90 (1.86–6.99) | 0.873 | ||
| Mean testicular volume (ml)e, median (5th–95th centiles) | 8.0 (4.1–16.0) | 7.0 (2.2–13.4) | 0.014 | ||
| SCOS | 40/144 (27.8) | 66/81 (81.5) | <0.0001 | ||
| Hypospermatogenesis, n/total number (%) | 100/144 (69.4) | 8/81 (9.9) | <0.0001 | ||
| Maturation arrest, n/total number (%) | 4/144 (2.8) | 7/81 (8.6) | 0.050 | ||
a33 missing values; b1 missing value; c116 missing values; d40 missing values; e9 missing values. SCOS: Sertoli cell-only syndrome; CI: confidence interval; TESE: testicular sperm extraction; FSH: follicle-stimulating hormone